GEOapplication/xmlftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE298nnn/GSE298937/primaryOK200TranscriptomicsRattus norvegicusExpression profiling by high throughput sequencinghttps://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE298937GEOGSEfalseChanges in RNA expression underlying sustained antidepressant effectsWe performed RNA-seq profiling of the medial prefrontal cortex (mPFC) in Wistar Kyoto (WKY) rats, an animal model of treatment-resistant depression. The WKY rats were treated for 7 days with either K-4, a novel positive allosteric modulator of the α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (AMPAR), or racemic ketamine. After a 7-day drug withdrawal period, mPFC tissues were collected and subjected to RNA-seq analysis. This study contributes to a understanding of the molecular mechanisms underlying the sustained antidepressant effects of ketamine.2026/06/04GSE298937GSM9026248GSM9026249GSM9026246GSM9026247GSM9026253GSM9026254GSM9026251GSM9026252GSM902625025947298937Rattus norvegicus