{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE299nnn/GSE299220/"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Transcriptomics"],"species":["Nostoc sp. PCC 7120 = FACHB-418"],"gds_type":["Expression profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE299220"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"Rifampicin time-series of Nostoc sp. PCC 7120 under different nitrogen conditions","description":"The ability of microbes to adapt to highly dynamic environments depends on subtle post-transcriptional regulatory mechanisms. The interaction between antisense RNAs or small non-coding RNAs and their mRNA targets can alter their half-life, thereby playing a role in the adaptation to different physiological conditions. Here, we have used rifampicin, an antibiotic that inhibits transcription initiation, to estimate the half-life of all transcripts in Nostoc sp. PCC 7120, a heterocyst-forming cyanobacterium. The analysis of the rifampicin time-series under two different growth conditions has revealed new layers of post-transcriptional regulation that may include transcriptional interference events (collisions between two elongating RNA polymerases).","dates":{"publication":"2026/05/22"},"accession":"GSE299220","cross_references":{"GSM":["GSM9035369","GSM9035365","GSM9035376","GSM9035377","GSM9035366","GSM9035378","GSM9035367","GSM9035368","GSM9035379","GSM9035383","GSM9035372","GSM9035361","GSM9035362","GSM9035373","GSM9035374","GSM9035363","GSM9035375","GSM9035364","GSM9035380","GSM9035381","GSM9035370","GSM9035371","GSM9035360","GSM9035382"],"GPL":["35476"],"GSE":["299220"],"taxon":["Nostoc sp. PCC 7120 = FACHB-418"]}}