{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE299nnn/GSE299227/"]},"type":"primary"},"statusCodeValue":200,"statusCode":"OK"}],"scores":null,"additional":{"omics_type":["Genomics"],"species":["Mus musculus"],"gds_type":["Genome binding/occupancy profiling by high throughput sequencing"," Expression profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE299227"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"Pyruvate, lactate, and hypoxia reprogram murine CD8 T cell chromatin landscape","description":"To investigate how metabolic and environmental cues shape gene regulation and chromatin accessibility in T cells, CD8 T cells were isolated from mice, activated in vitro, and exposed to lactate, pyruvate, sodium chloride, or hypoxic conditions. On day 3 post-activation, cells were harvested for RNA-seq and ATAC-seq analyses. This integrative approach enabled the identification of transcriptional and epigenetic changes in response to distinct metabolic and oxygen availability conditions","dates":{"publication":"2026/06/01"},"accession":"GSE299227","cross_references":{"GSM":["GSM9035611","GSM9035600","GSM9035612","GSM9035601","GSM9035613","GSM9035602","GSM9035614","GSM9035603","GSM9035596","GSM9035597","GSM9035598","GSM9035610","GSM9035599","GSM9035594","GSM9035595","GSM9035608","GSM9035609","GSM9035615","GSM9035604","GSM9035616","GSM9035605","GSM9035617","GSM9035606","GSM9035607"],"GPL":["17021","19057"],"GSE":["299227"],"taxon":["Mus musculus"]}}