GEOapplication/xmlftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE299nnn/GSE299227/primaryOK200GenomicsMus musculusGenome binding/occupancy profiling by high throughput sequencing Expression profiling by high throughput sequencinghttps://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE299227GEOGSEfalsePyruvate, lactate, and hypoxia reprogram murine CD8 T cell chromatin landscapeTo investigate how metabolic and environmental cues shape gene regulation and chromatin accessibility in T cells, CD8 T cells were isolated from mice, activated in vitro, and exposed to lactate, pyruvate, sodium chloride, or hypoxic conditions. On day 3 post-activation, cells were harvested for RNA-seq and ATAC-seq analyses. This integrative approach enabled the identification of transcriptional and epigenetic changes in response to distinct metabolic and oxygen availability conditions2026/06/01GSE299227GSM9035611GSM9035600GSM9035612GSM9035601GSM9035613GSM9035602GSM9035614GSM9035603GSM9035596GSM9035597GSM9035598GSM9035610GSM9035599GSM9035594GSM9035595GSM9035608GSM9035609GSM9035615GSM9035604GSM9035616GSM9035605GSM9035617GSM9035606GSM90356071702119057299227Mus musculus