{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE299nnn/GSE299395/"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Transcriptomics"],"species":["Homo sapiens"],"gds_type":["Expression profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE299395"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"RNA-seq of B-cell lymphoma treated with Ibrutinib and CAR T cells","description":"This dataset presents RNA sequencing (RNA-seq) data from human B-cell lymphoma HT tumors established in immunodeficient mice. Tumors were treated with ibrutinib (IB), CD19-directed chimeric antigen receptor T cells (CAR T cells), or a combination of both. The study aimed to investigate transcriptomic changes and treatment-related gene expression differences induced by monotherapy or combination therapy. These data provide insight into the molecular responses to IB and CAR T-cell treatment in vivo and may help elucidate mechanisms underlying therapeutic synergy.","dates":{"publication":"2026/06/10"},"accession":"GSE299395","cross_references":{"GSM":["GSM9038611","GSM9038610","GSM9038608","GSM9038609"],"GPL":["24676"],"GSE":["299395"],"taxon":["Homo sapiens"]}}