{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE299nnn/GSE299445/"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Transcriptomics"],"species":["Homo sapiens"],"gds_type":["Expression profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE299445"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"Taxodione Inhibits Glioblastoma Proliferation and Potentiates the Cytotoxicity of Paclitaxel","description":"Glioblastoma rapidly acquires resistance to conventional genotoxic therapy. This behavior is closely associated with the enhancement of stem-cell-like character during disease progression. Farnesyl diphosphate synthase (FDPS) plays an important role in maintaining such stem-cell-like features. This finding has stimulated interest in FDPS as neuro-oncology drug target; however, the lack of CNS-permeable inhibitors has hampered further development. In this study, we explored the utility of taxodione, a diterpenoid described as an FDPS inhibitor and predicted to penetrate the blood-brain-barrier. The effects of taxodione were compared to its congener 7-(2-oxohexyl)-taxodione and a known FDPS inhibitor in glioblastoma cells. Taxodione was the only treatment that significantly reduced the size of tumor spheroids in a temporal and dose-dependent manner. This activity was linked to FDPS inhibition and transcriptional downregulation of other Mevalonate Pathway genes. Consistent with this putative mechanism-of-action, taxodione sensitized glioblastoma cells to nanomolar concentrations of paclitaxel.","dates":{"publication":"2026/06/12"},"accession":"GSE299445","cross_references":{"GSM":["GSM9039329","GSM9039327","GSM9039328","GSM9039325","GSM9039326","GSM9039323","GSM9039324","GSM9039332","GSM9039321","GSM9039322","GSM9039330","GSM9039331"],"GPL":["24676"],"GSE":["299445"],"taxon":["Homo sapiens"]}}