{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE299nnn/GSE299458/"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Methylation profiling"],"species":["Mus musculus"],"gds_type":["Methylation profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE299458"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"Methylome profiling of SetDB1 deficient ESCs reveals coordinated epigenetic cross-talk during pluripotency","description":"DNA methylation profiling using whole-genome bisulfite sequencing of conditional SetDB1 knockout (KO) mouse embryonic stem cells (ESCs). Induction with 4-hydroxytamoxifen (4-OHT) facilitated the deletion of Setdb1 floxed exons 15 and 16, resulting in loss of SetDB1. Methylomes were profiled in wildtype (WT) serum- and 2i-cultured ESCs, and on multiple days after inducing SetDB1 depletion. Study also includes methylome profiles of ESCs undergoing simultaneous SetDB1 depletion and 2i-adaptation.","dates":{"publication":"2026/06/10"},"accession":"GSE299458","cross_references":{"GSM":["GSM9039479","GSM9039477","GSM9039478","GSM9039475","GSM9039476","GSM9039484","GSM9039473","GSM9039485","GSM9039474","GSM9039482","GSM9039483","GSM9039480","GSM9039481"],"GPL":["13112"],"GSE":["299458"],"taxon":["Mus musculus"]}}