GEOapplication/xmlftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE299nnn/GSE299458/primaryOK200Methylation profilingMus musculusMethylation profiling by high throughput sequencinghttps://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE299458GEOGSEfalseMethylome profiling of SetDB1 deficient ESCs reveals coordinated epigenetic cross-talk during pluripotencyDNA methylation profiling using whole-genome bisulfite sequencing of conditional SetDB1 knockout (KO) mouse embryonic stem cells (ESCs). Induction with 4-hydroxytamoxifen (4-OHT) facilitated the deletion of Setdb1 floxed exons 15 and 16, resulting in loss of SetDB1. Methylomes were profiled in wildtype (WT) serum- and 2i-cultured ESCs, and on multiple days after inducing SetDB1 depletion. Study also includes methylome profiles of ESCs undergoing simultaneous SetDB1 depletion and 2i-adaptation.2026/06/10GSE299458GSM9039479GSM9039477GSM9039478GSM9039475GSM9039476GSM9039484GSM9039473GSM9039485GSM9039474GSM9039482GSM9039483GSM9039480GSM903948113112299458Mus musculus