{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE299nnn/GSE299622/"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Transcriptomics"],"species":["Homo sapiens"],"gds_type":["Expression profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE299622"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"Transcriptome regulation in iPSC and astrocyte derived from CLN3 deficient patient","description":"CLN3 Batten disease is a severe pediatric neurodegenerative disorder caused by mutations in the CLN3 gene, most commonly a 1 kb deletion affecting exons 7 and 8. While research has focused on neuronal dysfunction, glial cells are increasingly recognized as key contributors to disease pathology. Here, we establish the iPSC and astrocyte model derived from a CLN3 patient fibrpblast cells with the 1 kb deletion and analyse the transcriptome regulation in both iPSC and astrocyte stages.","dates":{"publication":"2026/09/09"},"accession":"GSE299622","cross_references":{"GSM":["GSM9042130","GSM9042131","GSM9042120","GSM9042121","GSM9042122","GSM9042123","GSM9042124","GSM9042125","GSM9042126","GSM9042127","GSM9042128","GSM9042129"],"GPL":["23227"],"GSE":["299622"],"taxon":["Homo sapiens"],"PMID":["[42129767]"]}}