GEOapplication/xmlftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE299nnn/GSE299658/primaryOK200TranscriptomicsHomo sapiensExpression profiling by high throughput sequencinghttps://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE299658GEOGSEfalseScalable expansion and hepatic zone maturation of hepatic progenitor cells from human pluripotent stem cellsWe devised a method for large-scale manufacturing of hepatocytes derived from human pluripotent stem cells by modulating levels of FGF19, TGFβ and NOTCH. We further employed WNT inhibitor and agonist to enhance differentiation efficiency. These differentiation strategies produce hepatocytes cells with improved in vivo functionality and enable their application in 3D bioprinted liver tissue constructs.2026/06/11GSE299658GSM9043116GSM904311516791299658Homo sapiens