{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE299nnn/GSE299673/"]},"type":"primary"},"statusCodeValue":200,"statusCode":"OK"}],"scores":null,"additional":{"omics_type":["Methylation profiling"],"species":["Mus musculus"],"gds_type":["Methylation profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE299673"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"Reduced Representation Bisulfite Sequencing of Mouse Hearts Following Cardiomyocyte-Specific DNMT3A Overexpression","description":"Aging is associated with extensive epigenetic remodeling in cardiomyocytes, including increased DNA methylation. To investigate the causal role of DNA hypermethylation in age-related cardiac dysfunction, we overexpressed DNA methyltransferase 3A (DNMT3A) specifically in cardiomyocytes of young adult mice using a cardiac-specific AAV vector. Reduced representation bisulfite sequencing (RRBS) was performed on isolated cardiomyocyte nuclei from DNMT3A-overexpressing (Dnmt3a OE) and control (GFP) hearts. This dataset provides genome-wide DNA methylation profiles for both groups, enabling analysis of DNMT3A-driven methylome remodeling in the heart.","dates":{"publication":"2026/06/12"},"accession":"GSE299673","cross_references":{"GSM":["GSM9043484","GSM9043483","GSM9043486","GSM9043485","GSM9043488","GSM9043487","GSM9043489","GSM9043491","GSM9043490","GSM9043492"],"GPL":["34290"],"GSE":["299673"],"taxon":["Mus musculus"]}}