GEOapplication/xmlftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE299nnn/GSE299673/primary200OKMethylation profilingMus musculusMethylation profiling by high throughput sequencinghttps://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE299673GEOGSEfalseReduced Representation Bisulfite Sequencing of Mouse Hearts Following Cardiomyocyte-Specific DNMT3A OverexpressionAging is associated with extensive epigenetic remodeling in cardiomyocytes, including increased DNA methylation. To investigate the causal role of DNA hypermethylation in age-related cardiac dysfunction, we overexpressed DNA methyltransferase 3A (DNMT3A) specifically in cardiomyocytes of young adult mice using a cardiac-specific AAV vector. Reduced representation bisulfite sequencing (RRBS) was performed on isolated cardiomyocyte nuclei from DNMT3A-overexpressing (Dnmt3a OE) and control (GFP) hearts. This dataset provides genome-wide DNA methylation profiles for both groups, enabling analysis of DNMT3A-driven methylome remodeling in the heart.2026/06/12GSE299673GSM9043484GSM9043483GSM9043486GSM9043485GSM9043488GSM9043487GSM9043489GSM9043491GSM9043490GSM904349234290299673Mus musculus