{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE299nnn/GSE299983/"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Transcriptomics"],"species":["Homo sapiens"],"gds_type":["Expression profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE299983"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"Effect of METTL4 knockout on expression and splicing in HeLa S3 cells [human WT]","description":"In this work we studied the role of U2 snRNA m6A(m)30 modification introduced by METTL4 methyltransferase on a model of METTL4 knockout human cell line. METTL4 gene inactivation resulted in dysregulation of gene expression and alternative splicing, as well as general decrease in splicing speed and accuracy.","dates":{"publication":"2026/06/05"},"accession":"GSE299983","cross_references":{"GSM":["GSM9051376","GSM9051377","GSM9051375"],"GPL":["18460"],"GSE":["299983"],"taxon":["Homo sapiens"],"PMID":["[41354081]"]}}