GEOapplication/xmlftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE299nnn/GSE299983/primaryOK200TranscriptomicsHomo sapiensExpression profiling by high throughput sequencinghttps://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE299983GEOGSEfalseEffect of METTL4 knockout on expression and splicing in HeLa S3 cells [human WT]In this work we studied the role of U2 snRNA m6A(m)30 modification introduced by METTL4 methyltransferase on a model of METTL4 knockout human cell line. METTL4 gene inactivation resulted in dysregulation of gene expression and alternative splicing, as well as general decrease in splicing speed and accuracy.2026/06/05GSE299983GSM9051376GSM9051377GSM905137518460299983Homo sapiens[41354081]