{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Txt":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE300nnn/GSE300008/suppl/filelist.txt"],"Raw":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE300nnn/GSE300008/suppl/GSE300008_RAW.tar"],"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE300nnn/GSE300008/"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Genomics"],"species":["Mus musculus"],"gds_type":["Genome binding/occupancy profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE300008"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"Decoding the response to a PP2A inhibitor in pancreatic cancer","description":"The high failure rate of a cancer drug from target definition to clinical implementation highlights the need to prioritize context-specific targets. Here, we identify PP2A as an important target in pancreatic ductal adenocarcinoma (PDAC) by cancer-dependency scores. We characterized how inhibition of PP2A with the clinical grade inhibitor LB100 affects PDAC cells. Mesenchymal PDAC cells are highly susceptible to LB100-induced death. CRISPR-Cas9 drop-out screens revealed the contribution of the transcription cycle, splicing, or translation to the LB100 response. Mechanistically, PP2A inhibition disables the RNA polymerase II pause checkpoint, leading to CDK9-mediated transcriptional elongation linked to a ER stress response correlated with the formation of stress granules, autophagy, and cell death. We provide evidence for a PP2A inhibitor-sensitive subtype of PDAC and offer detailed insights into the cellular response induced by PP2A inhibitors.","dates":{"publication":"2026/06/18"},"accession":"GSE300008","cross_references":{"GSM":["GSM9052329","GSM9052338","GSM9052337","GSM9052324","GSM9052323","GSM9052332","GSM9052331","GSM9052330"],"GPL":["24247"],"GSE":["300008"],"taxon":["Mus musculus"],"PMID":["[42266180]"]}}