{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Txt":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE300nnn/GSE300038/suppl/filelist.txt"],"Raw":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE300nnn/GSE300038/suppl/GSE300038_RAW.tar"],"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE300nnn/GSE300038/"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Transcriptomics"],"species":["Homo sapiens"],"gds_type":["Expression profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE300038"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"Adipocytes are dispensable in shaping the ovarian cancer tumor microenvironment in the omentum","description":"The omentum, a specialized adipose tissue within the peritoneum, is a key metastatic niche for ovarian cancer (OC) dissemination during peritoneal carcinomatosis. The prevailing view is that omental adipocytes promote tumor growth by providinglipids, since global FABP4 deficiency curbs tumor growth. Here, we generated mice lacking mature adipocytes in the peritoneum and omentum. ID8p53–/–Brca2–/– , BPPNM, and KPCA OC cells retained a propensity to seed at regions typically associated with adipocytes, even without mature adipocytes. However, lack of mature adipocytes did not suppress peritoneal OC expansion, whereas removing the adipocyte-free omentum did. Murine and human single-cell RNA sequencing analysis revealed that endothelial FABP4 was high in the omentum. Indeed, endothelial cell-selective deficiency of FABP4 reduced OC growth in the peritoneum. These findings prompt a re-evaluation of adipocyte contributions to OC progression and point to a key role of the omental vasculature in supporting OC growth metabolically.","dates":{"publication":"2026/06/15"},"accession":"GSE300038","cross_references":{"GSM":["GSM9052754"],"GPL":["24676"],"GSE":["300038"],"taxon":["Homo sapiens"]}}