{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE300nnn/GSE300113/"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Transcriptomics"],"species":["Mus musculus"],"gds_type":["Expression profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE300113"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"Heterogenous microglial reactivity contrasts with stable vascular transcriptional programs in mouse models of Alzheimer’s, CADASIL, and Traumatic Brain Injury (Main dataset)","description":"The extent to which the cerebrovasculature is affected in various brain disorders is still not well understood. To address this, we established a transcriptomic repository of major vascular cell types and microglia to compare the transcriptomic response in mouse models of three human brain disorders linked to neuroinflammation and associated vascular reactivity: Alzheimer’s disease (AD), traumatic brain injury (TBI), and cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL). Single-cell analysis of >250,000 cells at different disease stages led to identification of two previously unknown vascular cell subtypes, expanded the endothelial zonation spectrum and allowed for a detailed analysis of the molecular responses in the vascular cells and microglia. Surprisingly, all vascular cell types remained transcriptomically normal across the three conditions, while microglia exhibited significant, disease-specific transcriptional changes. Notably, microglial responses converged between late-stage TBI and AD, offering new insights into the predisposition for neurodegeneration following TBI.","dates":{"publication":"2026/04/30"},"accession":"GSE300113","cross_references":{"GSM":["GSM9053874","GSM9053873","GSM9053872","GSM9053871","GSM9053870","GSM9053904","GSM9053903","GSM9053869","GSM9053902","GSM9053901","GSM9053868","GSM9053900","GSM9053867","GSM9053866","GSM9053865","GSM9053864","GSM9053909","GSM9053908","GSM9053907","GSM9053906","GSM9053905","GSM9053863","GSM9053862","GSM9053861","GSM9053860","GSM9053859","GSM9053858","GSM9053857","GSM9053856","GSM9053855","GSM9053899","GSM9053854","GSM9053898","GSM9053897","GSM9053853","GSM9053852","GSM9053896","GSM9053851","GSM9053895","GSM9053894","GSM9053893","GSM9053892","GSM9053891","GSM9053890","GSM9053889","GSM9053888","GSM9053887","GSM9053886","GSM9053885","GSM9053884","GSM9053883","GSM9053882","GSM9053881","GSM9053880","GSM9053879","GSM9053878","GSM9053877","GSM9053876","GSM9053875"],"GPL":["30172"],"GSE":["300113"],"taxon":["Mus musculus"]}}