GEOapplication/xmlftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE300nnn/GSE300132/primaryOK200TranscriptomicsHomo sapiensExpression profiling by high throughput sequencinghttps://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE300132GEOGSEfalseTranscriptome profiling of parental and lenvatinib-resistant TPC-1 thyroid cancer cellsTo uncover transcriptional alterations associated with lenvatinib resistance in papillary thyroid carcinoma, we performed paired-end RNA-Seq (2 × 150 bp, NovaSeq 6000) on parental TPC-1 cells and an in-house generated lenvatinib-resistant sub-line (TPC-1-Len). Total RNA from three biological replicates per group was extracted with TRIzol, libraries were prepared with poly(A) selection, and sequencing was carried out at OE Biotech (Shanghai, China). Differential gene expression was analysed using DESeq2 (Q < 0.05)2026/06/18GSE300132GSM9054262GSM9054261GSM9054260GSM9054265GSM9054264GSM905426324676300132Homo sapiens[41991644]