{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE300nnn/GSE300232/"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Other"],"species":["Arabidopsis thaliana"],"gds_type":[" Expression profiling by high throughput sequencing","Other"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE300232"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"RNA-seq and Ribo-seq analysis of Arabidopsis thaliana immune response","description":"In land plants, guard cells sense pathogens and close stomata to resist their entry. Pathogen-infected local leaves transmit the danger status to uninfected distal systemic leaves and trigger their stomatal closure as a global defense termed systemic stomatal immunity. However, the corresponding mobile signals remain unknown. Here, we report that an upstream open reading frame (uORF) encodes a long-distance mobile peptide inducing systemic stomatal closure and named uORF-encoded systemic stomatal immune conductor (USIC). In local leaves, USIC expression is upregulated upon pathogen/pattern signals. In systemic leaves, the SIRK1 receptor and KIN7 coreceptor perceives USIC, and induces KIN7 cleavage by MC4. KIN7 translocates to tonoplasts and mediates stomatal closure by associating with H+-ATPases and aquaporins. This study reveals a systemic signaling mechanism whereby an uORF-encoded mobile peptide and its receptor pathway activating systemic stomatal immunity.","dates":{"publication":"2026/05/01"},"accession":"GSE300232","cross_references":{"GSM":["GSM9056100","GSM9056089","GSM9056101","GSM9056102","GSM9056103","GSM9056104","GSM9056105","GSM9056106","GSM9056081","GSM9056082","GSM9056083","GSM9056084","GSM9056085","GSM9056086","GSM9056087","GSM9056088","GSM9056080","GSM9056079","GSM9056092","GSM9056093","GSM9056094","GSM9056095","GSM9056096","GSM9056097","GSM9056098","GSM9056099","GSM9056090","GSM9056091"],"GPL":["26208"],"GSE":["300232"],"taxon":["Arabidopsis thaliana"],"PMID":["[41605207]"]}}