GEOapplication/xmlftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE300nnn/GSE300232/primaryOK200OtherArabidopsis thaliana Expression profiling by high throughput sequencingOtherhttps://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE300232GEOGSEfalseRNA-seq and Ribo-seq analysis of Arabidopsis thaliana immune responseIn land plants, guard cells sense pathogens and close stomata to resist their entry. Pathogen-infected local leaves transmit the danger status to uninfected distal systemic leaves and trigger their stomatal closure as a global defense termed systemic stomatal immunity. However, the corresponding mobile signals remain unknown. Here, we report that an upstream open reading frame (uORF) encodes a long-distance mobile peptide inducing systemic stomatal closure and named uORF-encoded systemic stomatal immune conductor (USIC). In local leaves, USIC expression is upregulated upon pathogen/pattern signals. In systemic leaves, the SIRK1 receptor and KIN7 coreceptor perceives USIC, and induces KIN7 cleavage by MC4. KIN7 translocates to tonoplasts and mediates stomatal closure by associating with H+-ATPases and aquaporins. This study reveals a systemic signaling mechanism whereby an uORF-encoded mobile peptide and its receptor pathway activating systemic stomatal immunity.2026/05/01GSE300232GSM9056100GSM9056089GSM9056101GSM9056102GSM9056103GSM9056104GSM9056105GSM9056106GSM9056081GSM9056082GSM9056083GSM9056084GSM9056085GSM9056086GSM9056087GSM9056088GSM9056080GSM9056079GSM9056092GSM9056093GSM9056094GSM9056095GSM9056096GSM9056097GSM9056098GSM9056099GSM9056090GSM905609126208300232Arabidopsis thaliana[41605207]