{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Txt":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE300nnn/GSE300281/suppl/GSE300281_All_samples_normalized_counts.txt.gz","ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE300nnn/GSE300281/suppl/filelist.txt"],"Raw":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE300nnn/GSE300281/suppl/GSE300281_RAW.tar"],"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE300nnn/GSE300281/"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Transcriptomics"],"species":["Mus musculus"],"gds_type":["Expression profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE300281"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"Transcriptional profiling of AGPS knockout breast cancer cells treated with TGF-B","description":"This study investigates the transcriptional changes associated with depleting ether lipids via AGPS (alkylglycerone phosphate synthase) knockout in epithelial PyMT-1099 murine breast cancer cells. RNA-Seq was performed to compare the gene expression profiles between AGPS knockout and control cells, both in the presence and absence of TGF-B treatment. The data provide insights into how ether lipid metabolism intersects with TGF-B-mediated signaling pathways and epithelial-to-mesenchymal transition (EMT) in breast cancer.","dates":{"publication":"2026/06/18"},"accession":"GSE300281","cross_references":{"GSM":["GSM9057377","GSM9057376","GSM9057379","GSM9057378","GSM9057380","GSM9057373","GSM9057375","GSM9057374"],"GPL":["17021"],"GSE":["300281"],"taxon":["Mus musculus"]}}