{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE300nnn/GSE300378/"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Transcriptomics"],"species":["Homo sapiens"],"gds_type":["Expression profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE300378"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"Targeting Thioredoxin Reductase 1 (TrxR1) Uncovers Ferroptosis-Linked Transcriptional Vulnerabilities in Lung Cancer","description":"Bulk RNA sequencing revealed that KRAS-WT and EGFR-MUT LC cells, which are sensitive to TrxR1 inhibitors (CS47 and auranofin), undergo extensive transcriptional reprogramming, unlike the treatment-resistant KRAS-mutant (KRAS-MUT) cells. TrxR inhibition triggers robust transcriptional activation of glutathione biosynthesis, antioxidant defenses, and iron metabolism in KRAS-WT lung cancer cells. This adaptive response, while aimed at maintaining redox balance, is ultimately overwhelmed, leading to ferroptotic cell death.","dates":{"publication":"2026/06/30"},"accession":"GSE300378","cross_references":{"GSM":["GSM9059336","GSM9059314","GSM9059315","GSM9059337","GSM9059312","GSM9059334","GSM9059335","GSM9059313","GSM9059318","GSM9059319","GSM9059338","GSM9059316","GSM9059339","GSM9059317","GSM9059332","GSM9059333","GSM9059311","GSM9059330","GSM9059331","GSM9059325","GSM9059326","GSM9059323","GSM9059324","GSM9059329","GSM9059327","GSM9059328","GSM9059340","GSM9059343","GSM9059321","GSM9059322","GSM9059341","GSM9059342","GSM9059320"],"GPL":["18573"],"GSE":["300378"],"taxon":["Homo sapiens"]}}