GEOapplication/xmlftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE300nnn/GSE300378/primaryOK200TranscriptomicsHomo sapiensExpression profiling by high throughput sequencinghttps://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE300378GEOGSEfalseTargeting Thioredoxin Reductase 1 (TrxR1) Uncovers Ferroptosis-Linked Transcriptional Vulnerabilities in Lung CancerBulk RNA sequencing revealed that KRAS-WT and EGFR-MUT LC cells, which are sensitive to TrxR1 inhibitors (CS47 and auranofin), undergo extensive transcriptional reprogramming, unlike the treatment-resistant KRAS-mutant (KRAS-MUT) cells. TrxR inhibition triggers robust transcriptional activation of glutathione biosynthesis, antioxidant defenses, and iron metabolism in KRAS-WT lung cancer cells. This adaptive response, while aimed at maintaining redox balance, is ultimately overwhelmed, leading to ferroptotic cell death.2026/06/30GSE300378GSM9059336GSM9059314GSM9059315GSM9059337GSM9059312GSM9059334GSM9059335GSM9059313GSM9059318GSM9059319GSM9059338GSM9059316GSM9059339GSM9059317GSM9059332GSM9059333GSM9059311GSM9059330GSM9059331GSM9059325GSM9059326GSM9059323GSM9059324GSM9059329GSM9059327GSM9059328GSM9059340GSM9059343GSM9059321GSM9059322GSM9059341GSM9059342GSM905932018573300378Homo sapiens