GEOapplication/xmlftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE300nnn/GSE300551/primaryOK200Transcriptomics Mus musculusHomo sapiens OtherExpression profiling by high throughput sequencinghttps://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE300551GEOGSEfalseMassively multiplex multi-modal chemical screens at single-cell resolution with icCITE-plexWe present icCITE-plex, a novel cellular barcoding systems that enable multiplexed analysis of multiple independent samples within a single experiment through a combination of viral barcodes and antibody-based plate-barcodes. Using this platform, we successfully profiled 360 drug-dose responses across 475 surface proteins, 64 intracellular epitopes, and the whole transcriptome in human and mouse T cells treated with 56 different kinase inhibitors, demonstrating the method's ability to capture multi-modal cellular responses to chemical perturbations.2026/04/14GSE300551GSM9064448GSM9064449GSM9064468GSM9064446GSM9064447GSM9064469GSM9064455GSM9064456GSM9064453GSM9064454GSM9064451GSM9064452GSM9064450GSM9064459GSM9064457GSM9064458GSM9064466GSM9064467GSM9064445GSM9064464GSM9064465GSM9064462GSM9064463GSM9064460GSM906446125526300551 Mus musculusHomo sapiens