GEOapplication/xmlftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE300nnn/GSE300554/primaryOK200TranscriptomicsMus musculusExpression profiling by high throughput sequencinghttps://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE300554GEOGSEfalseImmune dysregulation in the prostates of C57BL/6Aire-/- mice mirrors that seen in BPHBPH represents the most prevalent urologic condition affecting aging men and causes considerable morbidity. The pathology is multifaceted, characterized by both stromal and epithelial cell proliferation, tissue fibrosis, lower urinary tract symptoms, and concurrent inflammatory processes. To model human benign prostatic hyperplasia (BPH), we employed 10X Genomics single-cell RNA sequencing to investigate prostate inflammation in C57BL/6 Aire-/- mice.The Aire-deficient mouse model provides a chronic inflammatory environment with intact immune responses, differing only in impaired central immune tolerance. The resulting datasets were subsequently compared against existing human BPH single-cell RNA sequencing data to validate the model's relevance.2026/05/27GSE300554GSM9064488GSM9064486GSM9064487GSM906448524247300554Mus musculus