{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE300nnn/GSE300563/"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Transcriptomics"],"species":["Mus musculus"],"gds_type":["Expression profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE300563"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"RNA-seq analysis for the Fluo-4 abnormal myofibers in aged mice","description":"In a rapidly aging society, the age-related decline in muscle mass and force, sarcopenia, is an urgent medical and economic issue. However, the molecular mechanisms of sarcopenia are still largely unknown. Using Ca2+ indicator Fluo-4, we identified the presence of the Fluo-4 abnormal muscle fibers only in aged mice. The Fluo-4 abnormal muscle fibers had a tubular aggregate-like structure and morphologically abnormal mitochondria. Furthermore, a cluster of mitochondria-related genes, including mitochondrially-encoded genes, were downregulated in Ca2+-abnormal muscle fibers. These results indicate that the Fluo-4 abnormal muscle fibers are accumulated in aged mice, and that age-related mitochondrial abnormalities are more prominent in these fibers.","dates":{"publication":"2026/04/23"},"accession":"GSE300563","cross_references":{"GSM":["GSM9064590","GSM9064591","GSM9064589","GSM9064598","GSM9064599","GSM9064588","GSM9064596","GSM9064597","GSM9064594","GSM9064595","GSM9064592","GSM9064593"],"GPL":["24247"],"GSE":["300563"],"taxon":["Mus musculus"]}}