GEOapplication/xmlftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE300nnn/GSE300563/primaryOK200TranscriptomicsMus musculusExpression profiling by high throughput sequencinghttps://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE300563GEOGSEfalseRNA-seq analysis for the Fluo-4 abnormal myofibers in aged miceIn a rapidly aging society, the age-related decline in muscle mass and force, sarcopenia, is an urgent medical and economic issue. However, the molecular mechanisms of sarcopenia are still largely unknown. Using Ca2+ indicator Fluo-4, we identified the presence of the Fluo-4 abnormal muscle fibers only in aged mice. The Fluo-4 abnormal muscle fibers had a tubular aggregate-like structure and morphologically abnormal mitochondria. Furthermore, a cluster of mitochondria-related genes, including mitochondrially-encoded genes, were downregulated in Ca2+-abnormal muscle fibers. These results indicate that the Fluo-4 abnormal muscle fibers are accumulated in aged mice, and that age-related mitochondrial abnormalities are more prominent in these fibers.2026/04/23GSE300563GSM9064590GSM9064591GSM9064589GSM9064598GSM9064599GSM9064588GSM9064596GSM9064597GSM9064594GSM9064595GSM9064592GSM906459324247300563Mus musculus