{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE300nnn/GSE300827/"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Other"],"species":["Homo sapiens"],"gds_type":["Other"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE300827"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"Spatial transcriptome of pre-invasive lung adenocarcinoma","description":"We observed distinct mutational patterns across stages: EGFR mutations increased with pathological stages, while non-V600E BRAF mutations were enriched in AAH and AIS, suggesting pre-invasive lesions harboring different drivers follow distinct evolutionary paths. Based on these differences, we derived 23-gene and 59-gene signatures that stratified pre-invasive lesions into aggressive and non-aggressive groups. The aggressive signature was associated with worse prognosis supported by five stage-I LUAD cohorts. Two aggressive signature genes, LPGAT1 and XPR1, were functionally validated to promote LUAD cell invasion. Compared to non-aggressive lesions, aggressive lesions exhibited higher tumor mutation burden, enrichment of proliferative and EMT-related pathways, and evidence of immune-stromal remodeling.","dates":{"publication":"2026/06/30"},"accession":"GSE300827","cross_references":{"GSM":["GSM9069319","GSM9069308","GSM9069309","GSM9069322","GSM9069311","GSM9069323","GSM9069312","GSM9069313","GSM9069314","GSM9069315","GSM9069304","GSM9069305","GSM9069316","GSM9069317","GSM9069306","GSM9069318","GSM9069307","GSM9069320","GSM9069321","GSM9069310"],"GPL":["24676"],"GSE":["300827"],"taxon":["Homo sapiens"]}}