{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE300nnn/GSE300942/"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Genomics"],"species":["Homo sapiens"],"gds_type":["Non-coding RNA profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE300942"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"A Prospective Pilot Study of Urine microRNA as a Biomarker of Urinary Toxicity Following MRI-Guided Prostate Stereotactic Body Radiotherapy","description":"Urinary toxicities are common following prostate radiotherapy and can significantly impact quality of life. There is a need for biomarkers that can predict the risk of urinary toxicity following treatment using MRI guided stereotactic body radiotherapy (MR-SBRT) to assist with selection of the most appropriate radiotherapy treatment approach and to potentially provide early intervention for toxicities. Many studies demonstrated the applicability of miRNA from bodily fluids as biomarkers; thus, we decided to check if urine-derived miRNA can serve as radiation toxicity predictors. Both sequencing and confirmatory targeted qPCR showed that expressions of miR-26a-5p and miR-95-3p decrease during MR-SBRT and begin to increase during early follow up. Levels of miR-204-3p and miR-192-5p behave differently in patients with and without urinary toxicity. Expression of miR-375-3p is lower in patients with higher risk category at all timepoints and tends to drop during and after MR-SBRT, especially in patients with lower risk category. These results warrant further studies on urine miRNAs as non-invasively measured biomarkers.","dates":{"publication":"2026/09/17"},"accession":"GSE300942","cross_references":{"GSM":["GSM9072530","GSM9072523","GSM9072522","GSM9072521","GSM9072520","GSM9072527","GSM9072526","GSM9072525","GSM9072524","GSM9072529","GSM9072528","GSM9072512","GSM9072534","GSM9072533","GSM9072511","GSM9072532","GSM9072531","GSM9072516","GSM9072515","GSM9072537","GSM9072536","GSM9072514","GSM9072535","GSM9072513","GSM9072519","GSM9072518","GSM9072517"],"GPL":["30882"],"GSE":["300942"],"taxon":["Homo sapiens"]}}