{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE300nnn/GSE300965/"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Transcriptomics"],"species":["Mus musculus"],"gds_type":["Expression profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE300965"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"Labile iron supply governs CD8+ T cell activation and function in metabolic health and obesity","description":"Sufficient nutrient supply is critical for CD8+ T cell activation and functions, but the role of labile iron remains unclear. Here, we find a rapid increase in the supply of labile iron in CD8+ T cells upon T-cell receptor activation. Blocking labile iron supply blunts Fe2+ influx into mitochondria and ROS production, hindering CD8+ T cell activation, while excessive labile iron content causes hyperactivation. Disrupted labile iron supply impairs the maintenance of adipose tissue CD8+ T cells. In obesity, an increase in Fe2+ influx into mitochondria enhances adipose tissue CD8+ cell functions, but weight loss normalizes CD8+ T cell iron metabolism. CD8+ cell-specific NRF2 activation boosts ferritin and lowers mitochondrial Fe2+ and ROS content in adipose tissue CD8+ cells, attenuating obesity-related adipose tissue inflammation and metabolic disorders. These results highlight the crucial role of labile iron supply in CD8+ T cell activation.","dates":{"publication":"2026/09/23"},"accession":"GSE300965","cross_references":{"GSM":["GSM9072798","GSM9072797","GSM9072796","GSM9072802","GSM9072801","GSM9072800","GSM9072799","GSM9072806","GSM9072805","GSM9072804","GSM9072803","GSM9072807"],"GPL":["34290"],"GSE":["300965"],"taxon":["Mus musculus"],"PMID":["[41241023]"]}}