{"database":"GEO","file_versions":[],"scores":null,"additional":{"omics_type":["Transcriptomics"],"species":["Mus musculus"],"gds_type":["Expression profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE301044"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"HTR2B Enhances the Phagocytosis of Brain Macrophages and Alleviates Brain Injury after Stroke","description":"This study employs single-cell RNA sequencing to investigate the dynamic changes in monocytic-macrophage populations in the brain following ischemic stroke. We analyzed brain tissues from mice subjected to middle cerebral artery occlusion (MCAO) for 3 days. Additionally, we compared the macrophage transcriptomes between Htr2bfl/fl and Lyz2creHtr2b mice to elucidate the impact of HTR2B deficiency on macrophage responses 3d-post-stroke. Our findings provide novel insights into the role of HTR2B in regulating macrophage behavior and its potential implications in stroke pathogenesis and recovery.","dates":{"publication":"2026/06/01"},"accession":"GSE301044","cross_references":{"GSM":["GSM9074155","GSM9074156"],"GPL":["24247"],"GSE":["301044"],"taxon":["Mus musculus"]}}