{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE301nnn/GSE301512/"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Genomics"],"species":["Homo sapiens"],"gds_type":["Genome binding/occupancy profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE301512"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"Chromatin topology dynamics of dexamethasone-treated trabecular meshwork identifies 78 causal genes for intraocular pressure and primary open angle glaucoma [CUT&Run]","description":"The physiology of trabecular meshwork (TM) controls aqueous humor outflow resistance and thereby intraocular pressure (IOP), a major risk factor for primary open-angle glaucoma (POAG). To decipher how GWAS-identified non-coding variants contribute to IOP and POAG, we generated a high-resolution map of genome topology and regulatory modules from primary human TM cell lines. Integrated analyses with dexamethasone-treated TM cells, a model of augmented IOP, demonstrate extensive changes in chromatin compartments, accessibility, looping, and histone marks that are highly concordant with transcriptional changes. By combining GWAS-associated variants with dexamethasone-induced chromatin looping, we discovered 26 IOP- and 52 POAG- candidate causal genes, belonging to key TM pathways, including integrin, transcriptional regulation of VENTX, and TNF signaling. Our studies provide a mechanistic framework for elucidating genetic complexity of IOP and pathogenesis of POAG and suggest new targets for therapies.","dates":{"publication":"2026/04/10"},"accession":"GSE301512","cross_references":{"GSM":["GSM9084512","GSM9084534","GSM9084535","GSM9084513","GSM9084532","GSM9084510","GSM9084533","GSM9084511","GSM9084538","GSM9084516","GSM9084539","GSM9084517","GSM9084536","GSM9084514","GSM9084515","GSM9084537","GSM9084518","GSM9084519","GSM9084520","GSM9084523","GSM9084524","GSM9084521","GSM9084522","GSM9084527","GSM9084528","GSM9084525","GSM9084526","GSM9084529","GSM9084530","GSM9084531"],"GPL":["30173"],"GSE":["301512"],"taxon":["Homo sapiens"],"PMID":["[41890121]"]}}