{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE301nnn/GSE301522/"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Other"],"species":["Homo sapiens"],"gds_type":["Other"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE301522"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"Chromatin topology dynamics of dexamethasone-treated trabecular meshwork identifies 78 causal genes for intraocular pressure and primary open angle glaucoma [HiC]","description":"The physiology of trabecular meshwork (TM) controls aqueous humor outflow resistance and thereby intraocular pressure (IOP), a major risk factor for primary open-angle glaucoma (POAG). To decipher how GWAS-identified non-coding variants contribute to IOP and POAG, we generated a high-resolution map of genome topology and regulatory modules from primary human TM cell lines. Integrated analyses with dexamethasone-treated TM cells, a model of augmented IOP, demonstrate extensive changes in chromatin compartments, accessibility, looping, and histone marks that are highly concordant with transcriptional changes. By combining GWAS-associated variants with dexamethasone-induced chromatin looping, we discovered 26 IOP- and 52 POAG- candidate causal genes, belonging to key TM pathways, including integrin, transcriptional regulation of VENTX, and TNF signaling. Our studies provide a mechanistic framework for elucidating genetic complexity of IOP and pathogenesis of POAG and suggest new targets for therapies.","dates":{"publication":"2026/04/10"},"accession":"GSE301522","cross_references":{"GSM":["GSM9084754","GSM9084732","GSM9084733","GSM9084755","GSM9084730","GSM9084752","GSM9084753","GSM9084731","GSM9084736","GSM9084758","GSM9084759","GSM9084737","GSM9084756","GSM9084734","GSM9084757","GSM9084735","GSM9084738","GSM9084739","GSM9084761","GSM9084740","GSM9084760","GSM9084743","GSM9084744","GSM9084741","GSM9084742","GSM9084747","GSM9084725","GSM9084748","GSM9084726","GSM9084745","GSM9084724","GSM9084746","GSM9084729","GSM9084727","GSM9084749","GSM9084728","GSM9084750","GSM9084751"],"GPL":["30173"],"GSE":["301522"],"taxon":["Homo sapiens"],"PMID":["[41890121]"]}}