{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE301nnn/GSE301567/"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Transcriptomics"],"species":["Mus musculus"],"gds_type":["Expression profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE301567"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"Effect of MEK inhibiton on KrasQ61R mutant Lgr5-positive intestinal stem cells","description":"We have previously shown that KRAS hyperactivation depletes the Lgr5-positive intestinal stem cells. Here, we aim to address whether reducing the MAPK pathway output, by using a MEK inhibitor (Cobimetinib) is sufficient to restore expression of Lgr5-positive intestinal stem cell markers.","dates":{"publication":"2026/04/05"},"accession":"GSE301567","cross_references":{"GSM":["GSM9085445","GSM9085440","GSM9085443","GSM9085444","GSM9085441","GSM9085442"],"GPL":["15103"],"GSE":["301567"],"taxon":["Mus musculus"]}}