GEOapplication/xmlftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE301nnn/GSE301567/primaryOK200TranscriptomicsMus musculusExpression profiling by high throughput sequencinghttps://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE301567GEOGSEfalseEffect of MEK inhibiton on KrasQ61R mutant Lgr5-positive intestinal stem cellsWe have previously shown that KRAS hyperactivation depletes the Lgr5-positive intestinal stem cells. Here, we aim to address whether reducing the MAPK pathway output, by using a MEK inhibitor (Cobimetinib) is sufficient to restore expression of Lgr5-positive intestinal stem cell markers.2026/04/05GSE301567GSM9085445GSM9085440GSM9085443GSM9085444GSM9085441GSM908544215103301567Mus musculus