{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE301nnn/GSE301640/"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Transcriptomics"],"species":["Staphylococcus aureus"],"gds_type":["Expression profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE301640"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"Overcoming methicillin resistance in Staphylococcus aureus via metal ion disruption of bacterial metabolism","description":"PBT2 is a zinc ionophore which demonstrates antibacterial activity as a standalone agent, and can be combined with conventional antibiotics to resensitise resistant pathogens to bactericidal killing. This study reports the impact of PBT2+Zn on on the transcriptome of S. aureus USA300-HO-MR, highlighting the global genetic changes in response to PBT2+Zn induced metal disruption, comprising Zn intoxication and Mn depletion.","dates":{"publication":"2026/09/01"},"accession":"GSE301640","cross_references":{"GSM":["GSM9086812","GSM9086811","GSM9086810","GSM9086799","GSM9086798","GSM9086816","GSM9086815","GSM9086814","GSM9086813","GSM9086819","GSM9086818","GSM9086817","GSM9086823","GSM9086801","GSM9086800","GSM9086822","GSM9086821","GSM9086820","GSM9086827","GSM9086805","GSM9086804","GSM9086826","GSM9086825","GSM9086803","GSM9086824","GSM9086802","GSM9086809","GSM9086808","GSM9086807","GSM9086806","GSM9086828","GSM9086793","GSM9086797","GSM9086796","GSM9086795","GSM9086794"],"GPL":["34637"],"GSE":["301640"],"taxon":["Staphylococcus aureus"]}}