GEOapplication/xmlftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE301nnn/GSE301640/primaryOK200TranscriptomicsStaphylococcus aureusExpression profiling by high throughput sequencinghttps://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE301640GEOGSEfalseOvercoming methicillin resistance in Staphylococcus aureus via metal ion disruption of bacterial metabolismPBT2 is a zinc ionophore which demonstrates antibacterial activity as a standalone agent, and can be combined with conventional antibiotics to resensitise resistant pathogens to bactericidal killing. This study reports the impact of PBT2+Zn on on the transcriptome of S. aureus USA300-HO-MR, highlighting the global genetic changes in response to PBT2+Zn induced metal disruption, comprising Zn intoxication and Mn depletion.2026/09/01GSE301640GSM9086812GSM9086811GSM9086810GSM9086799GSM9086798GSM9086816GSM9086815GSM9086814GSM9086813GSM9086819GSM9086818GSM9086817GSM9086823GSM9086801GSM9086800GSM9086822GSM9086821GSM9086820GSM9086827GSM9086805GSM9086804GSM9086826GSM9086825GSM9086803GSM9086824GSM9086802GSM9086809GSM9086808GSM9086807GSM9086806GSM9086828GSM9086793GSM9086797GSM9086796GSM9086795GSM908679434637301640Staphylococcus aureus