{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE301nnn/GSE301693/"]},"type":"primary"},"statusCodeValue":200,"statusCode":"OK"}],"scores":null,"additional":{"omics_type":["Transcriptomics"],"species":["Mus musculus"],"gds_type":["Expression profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE301693"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"Aloe emodin alleviates ferroptosis mediated inhibition of cisplatin-induced osteogenic differentiation of BMSCS through Hippo-YAP1 signaling pathway","description":"Cisplatin (CDDP) chemotherapy induces bone loss partly by triggering ferroptosis and inhibiting osteogenic differentiation of bone marrow stromal cells (BMSCs). This study demonstrates that aloe-emodin (AE) rescues CDDP-impaired osteogenic differentiation in ST2 BMSCs by suppressing ferroptosis (reducing lipid peroxidation and iron accumulation), while concurrently enhancing death in 143B osteosarcoma cells. Mechanistically, AE activated the Hippo-YAP1 signaling pathway, increasing YAP1 protein levels and nuclear translocation. Bioinformatics and functional validation (YAP1 inhibitor Verteporfin and overexpression) confirmed that AE's anti-ferroptotic and pro-osteogenic effects critically depend on Hippo-YAP1 activation. Verteporfin abolished AE's protection, directly linking YAP1 to the reversal of CDDP-induced damage. This dual action of AE—bone protection via Hippo-YAP1-mediated ferroptosis inhibition in BMSCs and tumor suppression in osteosarcoma—highlights its therapeutic potential against chemotherapy-induced bone loss, revealing a novel strategy targeting the Hippo-YAP1-ferroptosis axis.","dates":{"publication":"2026/09/01"},"accession":"GSE301693","cross_references":{"GSM":["GSM9087469","GSM9087471","GSM9087470","GSM9087464","GSM9087472","GSM9087468","GSM9087467","GSM9087466","GSM9087465"],"GPL":["17021"],"GSE":["301693"],"taxon":["Mus musculus"]}}