{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE301nnn/GSE301769/"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Transcriptomics"],"species":["Mus musculus"],"gds_type":["Expression profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE301769"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"Dysregulated Proline Metabolism Contributes to Subretinal Fibrosis in Neovascular AMD: Therapeutic Potential of Prolyl-4-Hydroxylase Inhibition","description":"Subretinal fibrosis is a key pathological feature of late-stage neovascular age-related macular degeneration (nAMD), often leading to irreversible vision loss. To investigate early molecular changes underlying subretinal fibrosis, we performed transcriptomic analysis on JR5558 mice, a spontaneous model of retinal neovascularisation, at 4 and 8 weeks of age. Age-matched C57BL/6J mice were used as controls. Bulk RNA sequencing was performed on whole retinas to identify differentially expressed genes and enriched biological pathways.","dates":{"publication":"2026/08/10"},"accession":"GSE301769","cross_references":{"GSM":["GSM9088914","GSM9088915","GSM9088904","GSM9088905","GSM9088906","GSM9088910","GSM9088911","GSM9088912","GSM9088913","GSM9088907","GSM9088908","GSM9088909"],"GPL":["24247"],"GSE":["301769"],"taxon":["Mus musculus"]}}