GEOapplication/xmlftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE301nnn/GSE301769/primaryOK200TranscriptomicsMus musculusExpression profiling by high throughput sequencinghttps://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE301769GEOGSEfalseDysregulated Proline Metabolism Contributes to Subretinal Fibrosis in Neovascular AMD: Therapeutic Potential of Prolyl-4-Hydroxylase InhibitionSubretinal fibrosis is a key pathological feature of late-stage neovascular age-related macular degeneration (nAMD), often leading to irreversible vision loss. To investigate early molecular changes underlying subretinal fibrosis, we performed transcriptomic analysis on JR5558 mice, a spontaneous model of retinal neovascularisation, at 4 and 8 weeks of age. Age-matched C57BL/6J mice were used as controls. Bulk RNA sequencing was performed on whole retinas to identify differentially expressed genes and enriched biological pathways.2026/08/10GSE301769GSM9088914GSM9088915GSM9088904GSM9088905GSM9088906GSM9088910GSM9088911GSM9088912GSM9088913GSM9088907GSM9088908GSM908890924247301769Mus musculus