{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE301nnn/GSE301840/"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Transcriptomics"],"species":["Homo sapiens"],"gds_type":["Expression profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE301840"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"Life-saving left ventricular assist devices promote a transcriptomic signature favoring cardiac fatty acid metabolism, repair and anti-inflammation","description":"In this study, we performed single-nuclei RNA sequencing on heart samples from 6 end-stage heart failure patients (3 ischemic cardiomyopathy and 3 non-ischemic cardiomyopathy). Each of these patients was treated with a left ventricular assist device (LVAD). Analysis of the longitudinal effect of LVAD at the transcriptomic level revealed a common signature profile related to the glucocorticoid receptor, independent of etiologies. Specifically, four genes promoting cardiac fatty acid metabolism, repair, and anti-inflammatory action were highlighted: FKBP5, ZBTB16, FOXO3, and PDK4.","dates":{"publication":"2026/05/15"},"accession":"GSE301840","cross_references":{"GSM":["GSM9090706","GSM9090707","GSM9090704","GSM9090705","GSM9090702","GSM9090703","GSM9090700","GSM9090701","GSM9090698","GSM9090699","GSM9090708","GSM9090709"],"GPL":["24676"],"GSE":["301840"],"taxon":["Homo sapiens"],"PMID":["[42019320]"]}}