GEOapplication/xmlftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE301nnn/GSE301840/primaryOK200TranscriptomicsHomo sapiensExpression profiling by high throughput sequencinghttps://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE301840GEOGSEfalseLife-saving left ventricular assist devices promote a transcriptomic signature favoring cardiac fatty acid metabolism, repair and anti-inflammationIn this study, we performed single-nuclei RNA sequencing on heart samples from 6 end-stage heart failure patients (3 ischemic cardiomyopathy and 3 non-ischemic cardiomyopathy). Each of these patients was treated with a left ventricular assist device (LVAD). Analysis of the longitudinal effect of LVAD at the transcriptomic level revealed a common signature profile related to the glucocorticoid receptor, independent of etiologies. Specifically, four genes promoting cardiac fatty acid metabolism, repair, and anti-inflammatory action were highlighted: FKBP5, ZBTB16, FOXO3, and PDK4.2026/05/15GSE301840GSM9090706GSM9090707GSM9090704GSM9090705GSM9090702GSM9090703GSM9090700GSM9090701GSM9090698GSM9090699GSM9090708GSM909070924676301840Homo sapiens[42019320]