{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE302nnn/GSE302015/"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Transcriptomics"],"species":["Mus musculus"],"gds_type":["Expression profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE302015"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"Transcriptome signatures of SU-Eohyeol pharmacopuncture (SUEHP) in an MPTP-induced Parkinson's disease animal model","description":"Parkinson’s disease (PD) is a progressive neurodegenerative disorder for which no definitive cure currently exists. The disease is primarily characterized by motor symptoms such as muscle rigidity, bradykinesia, and postural instability, along with a range of non-motor symptoms including pain, depression, sleep disturbances, and cognitive impairment. Given the absence of comprehensive therapeutic approaches that can effectively address both motor and non-motor manifestations of PD, we sought to investigate the potential therapeutic efficacy of SUEHP, a modality derived from traditional East Asian medicine. A mouse model of PD was established via administration of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), followed by SUEHP treatment administered twice weekly for a duration of two weeks. Based on compositional analysis of the pharmacopuncture formulation, cannabinoid receptor 1 (CB1) and peroxisome proliferator-activated receptor gamma (PPARγ) were identified as potential molecular targets. To assess their involvement, selective antagonists or inhibitors were co-administered. Transcriptomic analysis was subsequently conducted to characterize gene expression alterations associated with SUEHP treatment and to elucidate underlying mechanisms of action.","dates":{"publication":"2026/06/10"},"accession":"GSE302015","cross_references":{"GSM":["GSM9094220","GSM9094221","GSM9094222","GSM9094200","GSM9094212","GSM9094213","GSM9094214","GSM9094215","GSM9094216","GSM9094217","GSM9094218","GSM9094219","GSM9094191","GSM9094192","GSM9094193","GSM9094194","GSM9094195","GSM9094196","GSM9094230","GSM9094197","GSM9094198","GSM9094210","GSM9094199","GSM9094211","GSM9094201","GSM9094223","GSM9094224","GSM9094202","GSM9094225","GSM9094203","GSM9094204","GSM9094226","GSM9094227","GSM9094205","GSM9094228","GSM9094206","GSM9094207","GSM9094229","GSM9094208","GSM9094209"],"GPL":["24247"],"GSE":["302015"],"taxon":["Mus musculus"],"PMID":["[42218674]"]}}