GEOapplication/xmlftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE302nnn/GSE302015/primaryOK200TranscriptomicsMus musculusExpression profiling by high throughput sequencinghttps://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE302015GEOGSEfalseTranscriptome signatures of SU-Eohyeol pharmacopuncture (SUEHP) in an MPTP-induced Parkinson's disease animal modelParkinson’s disease (PD) is a progressive neurodegenerative disorder for which no definitive cure currently exists. The disease is primarily characterized by motor symptoms such as muscle rigidity, bradykinesia, and postural instability, along with a range of non-motor symptoms including pain, depression, sleep disturbances, and cognitive impairment. Given the absence of comprehensive therapeutic approaches that can effectively address both motor and non-motor manifestations of PD, we sought to investigate the potential therapeutic efficacy of SUEHP, a modality derived from traditional East Asian medicine. A mouse model of PD was established via administration of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), followed by SUEHP treatment administered twice weekly for a duration of two weeks. Based on compositional analysis of the pharmacopuncture formulation, cannabinoid receptor 1 (CB1) and peroxisome proliferator-activated receptor gamma (PPARγ) were identified as potential molecular targets. To assess their involvement, selective antagonists or inhibitors were co-administered. Transcriptomic analysis was subsequently conducted to characterize gene expression alterations associated with SUEHP treatment and to elucidate underlying mechanisms of action.2026/06/10GSE302015GSM9094220GSM9094221GSM9094222GSM9094200GSM9094212GSM9094213GSM9094214GSM9094215GSM9094216GSM9094217GSM9094218GSM9094219GSM9094191GSM9094192GSM9094193GSM9094194GSM9094195GSM9094196GSM9094230GSM9094197GSM9094198GSM9094210GSM9094199GSM9094211GSM9094201GSM9094223GSM9094224GSM9094202GSM9094225GSM9094203GSM9094204GSM9094226GSM9094227GSM9094205GSM9094228GSM9094206GSM9094207GSM9094229GSM9094208GSM909420924247302015Mus musculus[42218674]