GEOapplication/xmlftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE302nnn/GSE302288/primaryOK200TranscriptomicsHomo sapiensExpression profiling by high throughput sequencinghttps://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE302288GEOGSEfalseBenzalkonium Chloride-Induced Nephrotoxicity in 2D Cultures and a Human Kidney-on-a-Chip SystemBenzalkonium chlorides (BACs) are quaternary ammonium compounds widely used in various consumer products and industries due to their broad spectrum anti-antimicrobial properties. Their mechanism of action is proposed through the perturbation and disruption of a lipid membrane with its amphiphilic structure, in which BACs consist of a positively charged nitrogen head group and long aliphatic tail consisting of various lengths (Merchel Piovesan Pereira & Tagkopoulos, 2019). Because of this mechanism, they are used as active ingredients in disinfectant and cleaning solutions (sprays, wipes and hand sanitizers), medical products (eye drops and nasal sprays), cosmetic and hygiene products, and used as sanitization tools in the agricultural and food processing industries (Merchel Piovesan Pereira & Tagkopoulos, 2019). Detectable levels of BACs on various food products (The Federal Institute for Risk Assessment (BfR) of Germany, 2012) as well as topical exposure to BACs through disinfectant application to various surfaces and mediums can lead to chronic and systemic exposure to humans. Major routes of exposure include ingestion, inhalation and dermal/ocular/nasal contact (US EPA, 2006). The COVID-19 pandemic has led to a dramatic increase in the usage of cleaning and disinfectant solutions in businesses and households, increasing the amount of indoor exposure to these compounds (Zheng et al., 2020).2026/06/23GSE302288GSM9101284GSM9101285GSM9101286GSM9101287GSM9101291GSM9101283GSM9101290GSM9101288GSM910128915520302288Homo sapiens[42184204]