{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE302nnn/GSE302359/"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Transcriptomics"],"species":["Homo sapiens"],"gds_type":["Expression profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE302359"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"Interferons promote autophagy via the STAT1/STAT5B-SOCS1 axis","description":"Concerted activation of the interferon (IFN) system and autophagy upon viral infection is paramount for efficient immune defences. Here, we show that IFN activates autophagy via STAT1/5B heterodimer-mediated upregulation of SOCS1 and contributes to virus-induced autophagy. Our data demonstrate that autophagic flux activation by type I and II IFNs peaks at 24 h post treatment, whereas type III IFNs induce autophagy with slower kinetics. Mechanistically, IFN-mediated autophagy induction is dependent on JAK1-3 and both STAT1 as well as STAT5B. We show that STAT1 and STAT5B form heterodimers and co-localize following IFN treatment. Transcriptome analyses revealed that SOCS1 is induced in a STAT5B-dependent manner, and depletion of SOCS1 prevented IFN-induced autophagy. Finally, pharmacological inhibition of STAT5B or scavenging of IFN diminishes autophagosome levels upon infection with Sendai, respiratory syncytial, measles and influenza A viruses. Taken together, our data indicate that the IFN system and autophagy are connected via the STAT1/STAT5B-SOCS1 axis and that this axis is required for concerted activation of both systems during viral infections. Targeting of this signalling axis may allow to boost autophagy against viral infections.","dates":{"publication":"2026/07/01"},"accession":"GSE302359","cross_references":{"GSM":["GSM9102628","GSM9102627","GSM9102638","GSM9102629","GSM9102635","GSM9102634","GSM9102637","GSM9102636","GSM9102631","GSM9102630","GSM9102633","GSM9102632"],"GPL":["30173"],"GSE":["302359"],"taxon":["Homo sapiens"]}}