GEOapplication/xmlftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE302nnn/GSE302399/primaryOK200TranscriptomicsHomo sapiens Non-coding RNA profiling by high throughput sequencingExpression profiling by high throughput sequencinghttps://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE302399GEOGSEfalseMultimodal Transcriptomic Profiling of T Cell Responses to Triple-Negative Breast Cancer-Derived ExosomesTriple-negative breast cancer (TNBC) is a highly aggressive and immunogenic subtype that lacks effective targeted therapies. Although tumor-derived exosomes are known to influence immune responses, their direct role in shaping human T cell plasticity and antigen specificity remains insufficiently characterized. In this study, we performed an integrative single-cell multiomic analysis of primary human T cells following exposure to exosomes isolated from 17 genomically distinct TNBC cell lines. By combining single-cell transcriptomics, T cell receptor (TCR) V(D)J sequencing, non-coding RNA profiling, and both bulk and single-cell cytokine analyses, we identified conserved and subtype-specific immunoregulatory programs elicited by TNBC-derived exosomes.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 sapiens