{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE302nnn/GSE302775/"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Transcriptomics"],"species":["Homo sapiens"],"gds_type":["Expression profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE302775"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"FABP4 binding cancer cells exhibit an invasive phenotype via PKC-mitoROS signaling","description":"Using several high-fat diet-induced murine obesity models, we demonstrate that obesity promotes breast cancer lung metastasis through elevated levels of adipocyte-derived circulating FABP4. Circulating FABP4 directly binds to a subset of breast cancer cells via the membrane lipid PIP2. This FABP4/PIP2 interaction activates PKC signaling and enhances mitochondrial ROS production, driving cancer cell migration. these findings identify circulating FABP4 as a critical mediator of obesity-driven metastasis and highlight it as a promising therapeutic target for treating metastatic breast cancer.","dates":{"publication":"2026/06/17"},"accession":"GSE302775","cross_references":{"GSM":["GSM9111095","GSM9111099","GSM9111098","GSM9111097","GSM9111096","GSM9111100"],"GPL":["24676"],"GSE":["302775"],"taxon":["Homo sapiens"]}}