{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE302nnn/GSE302955/"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Methylation profiling"],"species":["Homo sapiens"],"gds_type":["Methylation profiling by array"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE302955"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"DNA methylation profiling of PBMCs from 42 esophageal squamous cell carcinoma patients and 30 controls using the Illumina MethylationEPIC array","description":"Esophageal squamous cell carcinoma (ESCC) constitutes over 80% of esophageal cancer cases in China, with advanced-stage patients exhibiting a 5-year survival rate below 30%. Early diagnosis is critical for improving survival outcomes. Current clinical diagnostic methods present significant limitations. This study aimed to identify potential non-invasive biomarkers through epigenomic analysis of the DNA methylome in peripheral blood mononuclear cells (PBMCs) from ESCC patients. Using the Infinium MethylationEPIC (935K) array, we profiled genome-wide DNA methylation patterns in PBMCs from 42 ESCC patients and 30 controls. We discovered an episignature of 742 differentially methylated CpGs (DMCs) that effectively discriminates ESCC patients from controls.","dates":{"publication":"2026/09/25"},"accession":"GSE302955","cross_references":{"GSM":["GSM9114671","GSM9114672","GSM9114673","GSM9114674","GSM9114670","GSM9114679","GSM9114712","GSM9114713","GSM9114714","GSM9114715","GSM9114675","GSM9114676","GSM9114710","GSM9114677","GSM9114711","GSM9114678","GSM9114709","GSM9114705","GSM9114706","GSM9114707","GSM9114708","GSM9114660","GSM9114661","GSM9114662","GSM9114663","GSM9114668","GSM9114701","GSM9114702","GSM9114669","GSM9114703","GSM9114704","GSM9114664","GSM9114665","GSM9114666","GSM9114667","GSM9114700","GSM9114693","GSM9114694","GSM9114695","GSM9114696","GSM9114690","GSM9114691","GSM9114692","GSM9114730","GSM9114697","GSM9114731","GSM9114698","GSM9114699","GSM9114727","GSM9114728","GSM9114729","GSM9114682","GSM9114683","GSM9114684","GSM9114685","GSM9114680","GSM9114681","GSM9114723","GSM9114724","GSM9114725","GSM9114726","GSM9114686","GSM9114687","GSM9114720","GSM9114688","GSM9114721","GSM9114722","GSM9114689","GSM9114716","GSM9114717","GSM9114718","GSM9114719"],"GPL":["33022"],"GSE":["302955"],"taxon":["Homo sapiens"]}}