GEOapplication/xmlftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE302nnn/GSE302955/primaryOK200Methylation profilingHomo sapiensMethylation profiling by arrayhttps://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE302955GEOGSEfalseDNA methylation profiling of PBMCs from 42 esophageal squamous cell carcinoma patients and 30 controls using the Illumina MethylationEPIC arrayEsophageal squamous cell carcinoma (ESCC) constitutes over 80% of esophageal cancer cases in China, with advanced-stage patients exhibiting a 5-year survival rate below 30%. Early diagnosis is critical for improving survival outcomes. Current clinical diagnostic methods present significant limitations. This study aimed to identify potential non-invasive biomarkers through epigenomic analysis of the DNA methylome in peripheral blood mononuclear cells (PBMCs) from ESCC patients. Using the Infinium MethylationEPIC (935K) array, we profiled genome-wide DNA methylation patterns in PBMCs from 42 ESCC patients and 30 controls. We discovered an episignature of 742 differentially methylated CpGs (DMCs) that effectively discriminates ESCC patients from controls.2026/09/25GSE302955GSM9114671GSM9114672GSM9114673GSM9114674GSM9114670GSM9114679GSM9114712GSM9114713GSM9114714GSM9114715GSM9114675GSM9114676GSM9114710GSM9114677GSM9114711GSM9114678GSM9114709GSM9114705GSM9114706GSM9114707GSM9114708GSM9114660GSM9114661GSM9114662GSM9114663GSM9114668GSM9114701GSM9114702GSM9114669GSM9114703GSM9114704GSM9114664GSM9114665GSM9114666GSM9114667GSM9114700GSM9114693GSM9114694GSM9114695GSM9114696GSM9114690GSM9114691GSM9114692GSM9114730GSM9114697GSM9114731GSM9114698GSM9114699GSM9114727GSM9114728GSM9114729GSM9114682GSM9114683GSM9114684GSM9114685GSM9114680GSM9114681GSM9114723GSM9114724GSM9114725GSM9114726GSM9114686GSM9114687GSM9114720GSM9114688GSM9114721GSM9114722GSM9114689GSM9114716GSM9114717GSM9114718GSM911471933022302955Homo sapiens